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COVID-19: Britons aged 18-29 to be offered alternative to Oxford-AstraZeneca coronavirus jab where possible



Britons aged 18-29 will be offered an alternative to the Oxford-AstraZeneca vaccine following 79 people developing blood clots after the jab, government advisors have decided.

The Medicines and Healthcare Products Regulatory Agency (MHRA) concluded there is a possible link between the Oxford vaccine and “extremely rare and unlikely to occur” blood clots with lowered platelets.

Younger people are much less likely to die from COVID-19 so the Joint Committee on Vaccination and Immunisation (JCVI) has decided it is safer to advise that age group are offered a different jab, where possible.

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England’s deputy chief medical officer Professor Jonathan Van-Tam said the new advice is a “course correction” for the UK’s “very successful” vaccine rollout – and said for most age groups the “benefits outweigh the risks”.

He said the new advice will have a negligible impact on the UK’s vaccine rollout, which is continuing “full speed ahead”.

The advice is being given after a total of 79 people in the UK have had blood clots following their first Oxford-AstraZeneca jab up to the 31 March, Dr June Raine, chief executive of the MHRA said. More than 20m people have been given the Oxford vaccine.

Of those 70 people, 19 have died – three under the age of 30, she said.

A total of 51 women and 28 men aged 18 to 79 were affected but Professor Sir Munir Pirmohamed, chair of commission on human medicines, said there is no evidence women have a predilection to develop blood clots after having the Oxford jab.

“The risk is four people in a million,” Dr Raine added.

She said anybody suffering the following side effects four days after getting a jab should seek medical attention:

  • Headaches
  • Blurred vision
  • Shortness of breath
  • Chest pain
  • Leg swelling
  • Abdominal pain
  • Bruising or pinpoint spots beyond the vaccination site.

The JCVI has said people of any age who have received the first dose of the Oxford vaccine should continue to be offered the second dose according to schedule.

JCVI chairman Professor Wei Shen Lim said: “We are advising a preference of one vaccine over another vaccine for a particular age group out of utmost caution rather than any serious safety concerns.”

He added that people who are just over 29-years-old should make their decision, but getting the vaccine is much safer than not getting it.

Prof Van Tam said it is quite usual for physicians to alter their preference on medicines and vaccines, and said the NHS will get the “right vaccine to you at the right time” but said some people may have to travel further for their vaccines.

He said it remains “vitally important” that people get their vaccine when they are invited.

Currently, the UK is also rolling out the Pfizer jab, and the first doses of the Moderna vaccine were administered today in Wales. Mr Van Tam said Moderna jabs are expected in England in mid-April.

This afternoon, Boris Johnson said the government believes the Oxford/AstraZeneca vaccine is “safe”, telling reporters on a visit to Cornwall: “But the crucial thing for everybody is to listen to what the scientists, the medical experts have to say later on today.”

On the vaccination programme, he added: “You can really start to see some of the benefits of that – it’s pretty clear that the decline in the number of deaths, the decline in the number of hospitalisations is being fuelled, is being assisted, the steepness of that decline is being helped by the roll-out of the vaccines so it’s very important for everybody to continue to get your second jab when you’re asked to come forward for your turn.”

The development comes as the EU’s medicines regulator announced the conclusions of its own review, saying that “unusual blood clots” should be listed as a “very rare” side-effect.





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